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Avandia is indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus• Due to its mechanism of action, Avandia is active only in the presence of endogenous insulin. Therefore, Avandia should not be used in patients with type 1 diabetes mellitus or for the treatment of diabetic ketoacidosis. • The coadministration of Avandia and insulin is not recommended. • The use of Avandia with nitrates is not recommended

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